1: With hydrogenchloride in ethanol; water
T=70 - 80°C; 20 - 28 h;
2: With potassium carbonate in ethanol; water
T=10 - 20°C; Product distribution / selectivity;
参考文献
ASTEX THERAPEUTICS LIMITED
Patent: WO2007/77435 A1, 2007 ;
Location in patent: Page/Page column 245-246 ;
WO 2007/077435 A1