1: 92 percent / Et3N / benzene / 16 h / 20 °C 2: 55 percent / Et3N / acetonitrile / 16 h / 20 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098214', constants.ctx, '0')">hydrogenchloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1731042', constants.ctx, '0')">chloroform</a> <br />T=0&deg;C;&nbsp;Substitution;&nbsp;18&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 96 percent / DMAP / CHCl₃ / 48 h / 20 &deg;C<br />2: 73 percent / 12N HCl / CHCl₃; methanol / 18 h / 0 &deg;C<br /> <br /> &nbsp;