1: 60 percent / NaOEt / tetrahydrofuran / 5 h / Ambient temperature 2: 95 percent / N-benzylacridinium bromide / acetonitrile / 1 h 3: 82 percent / K2CO3, 2-ethoxyethanol / dimethylsulfoxide / 2 h / 80 °C 4: 70 percent / con HCl, H2 / 10percent Pd-C / ethanol / 3 h / 760 Torr View Scheme

1: 60 percent / NaOEt / tetrahydrofuran / 5 h / Ambient temperature 2: 95 percent / N-benzylacridinium bromide / acetonitrile / 1 h 3: 82 percent / K2CO3, 2-ethoxyethanol / dimethylsulfoxide / 2 h / 80 °C View Scheme