N-[2-(二甲基氨基)乙基]-12-氧代-12H-苯并[g]吡啶并[2,1-b]喹唑啉-4-甲酰胺合成路线 （共 3 条）
反应条件
1: 12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxylic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C; 0.25 h;
2: N,N-dimethylethylenediamine in N,N-dimethyl-formamide
16 h;
参考文献
Colis, Laureen; Ernst, Glen; Sanders, Sara; Liu, Hester; Sirajuddin, Paul; Peltonen, Karita; Depasquale, Michael; Barrow, James C.; Laiho, Marikki
Journal of Medicinal Chemistry, 2014 , vol. 57, # 11 p. 4950 - 4961
反应条件
1.1: hydrogenchloride / ethanol / 66 h / 80 °C
2.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C
2.2: 16 h
View Scheme
参考文献
Colis, Laureen; Ernst, Glen; Sanders, Sara; Liu, Hester; Sirajuddin, Paul; Peltonen, Karita; Depasquale, Michael; Barrow, James C.; Laiho, Marikki
Journal of Medicinal Chemistry, 2014 , vol. 57, # 11 p. 4950 - 4961
反应条件
1.1: hydrogenchloride / ethanol / 66 h / 80 °C
2.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C
2.2: 16 h
View Scheme
参考文献
Colis, Laureen; Ernst, Glen; Sanders, Sara; Liu, Hester; Sirajuddin, Paul; Peltonen, Karita; Depasquale, Michael; Barrow, James C.; Laiho, Marikki
Journal of Medicinal Chemistry, 2014 , vol. 57, # 11 p. 4950 - 4961
