1: 2-(dimethyl-λ4-sulfanylidene)-1-phenyl-ethanone With caesium carbonate in anhydrous xylene T=20°C; 0.5 h; 2: N-(2-chloromethyl-6-methyl-phenyl)-4-methyl-benzenesulfonamide in anhydrous xylene T=20 - 60°C;

sodium ethanolate in dimethyl sulfoxide T=100°C; 24 h; Inert atmosphere;

iodine; potassium carbonate in methanol T=60°C; 3 h;

sodium hydroxide in N,N-dimethyl-formamide

1.1: thionyl chloride / chloroform / 40 °C 2.1: caesium carbonate / anhydrous xylene / 0.5 h / 20 °C 2.2: 20 - 60 °C View Scheme

1: palladium diacetate; silver(l) oxide; dipotassium peroxodisulfate; acetic acid / 1,4-dioxane; dimethyl sulfoxide / 24 h / 130 °C / |Inert atmosphere; |Sealed tube 2: sodium ethanolate / dimethyl sulfoxide / 24 h / 100 °C / |Inert atmosphere View Scheme