6-甲基-1-(苯基磺酰基)-1H-吡咯并[2,3-b]吡啶合成路线 （共 6 条）
反应条件
sodium hydroxide in ethanol; water 8 h; Heating / reflux;
参考文献
Tung, Yen-Shih; Coumar, Mohane Selvaraj; Wu, Yu-Shan; Shiao, Hui-Yi; Chang, Jang-Yang; Liou, Jing-Ping; Shukla, Paritosh; Chang, Chun-Wei; Chang, Chi-Yen; Kuo, Ching-Chuan; Yeh, Teng-Kuang; Lin, Chin-Yu; Wu, Jian-Sung; Wu, Su-Ying; Liao, Chun-Chen; Hsieh, Hsing-Pang
Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 3076 - 3080
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
Negishi coupling reaction; 40 h; Inert atmosphereReflux;
参考文献
Tung, Yen-Shih; Coumar, Mohane Selvaraj; Wu, Yu-Shan; Shiao, Hui-Yi; Chang, Jang-Yang; Liou, Jing-Ping; Shukla, Paritosh; Chang, Chun-Wei; Chang, Chi-Yen; Kuo, Ching-Chuan; Yeh, Teng-Kuang; Lin, Chin-Yu; Wu, Jian-Sung; Wu, Su-Ying; Liao, Chun-Chen; Hsieh, Hsing-Pang
Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 3076 - 3080
反应条件
1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 2 h / 20 °C
2: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / Inert atmosphere
3: water; sodium hydroxide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
4: sodium hydroxide / dichloromethane / 8 h / 20 °C / Inert atmosphere
5: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 40 h / Inert atmosphere; Reflux
View Scheme
参考文献
Tung, Yen-Shih; Coumar, Mohane Selvaraj; Wu, Yu-Shan; Shiao, Hui-Yi; Chang, Jang-Yang; Liou, Jing-Ping; Shukla, Paritosh; Chang, Chun-Wei; Chang, Chi-Yen; Kuo, Ching-Chuan; Yeh, Teng-Kuang; Lin, Chin-Yu; Wu, Jian-Sung; Wu, Su-Ying; Liao, Chun-Chen; Hsieh, Hsing-Pang
Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 3076 - 3080
反应条件
1: water; sodium hydroxide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
2: sodium hydroxide / dichloromethane / 8 h / 20 °C / Inert atmosphere
3: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 40 h / Inert atmosphere; Reflux
View Scheme
参考文献
Tung, Yen-Shih; Coumar, Mohane Selvaraj; Wu, Yu-Shan; Shiao, Hui-Yi; Chang, Jang-Yang; Liou, Jing-Ping; Shukla, Paritosh; Chang, Chun-Wei; Chang, Chi-Yen; Kuo, Ching-Chuan; Yeh, Teng-Kuang; Lin, Chin-Yu; Wu, Jian-Sung; Wu, Su-Ying; Liao, Chun-Chen; Hsieh, Hsing-Pang
Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 3076 - 3080
反应条件
1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / Inert atmosphere
2: water; sodium hydroxide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
3: sodium hydroxide / dichloromethane / 8 h / 20 °C / Inert atmosphere
4: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 40 h / Inert atmosphere; Reflux
View Scheme
参考文献
Tung, Yen-Shih; Coumar, Mohane Selvaraj; Wu, Yu-Shan; Shiao, Hui-Yi; Chang, Jang-Yang; Liou, Jing-Ping; Shukla, Paritosh; Chang, Chun-Wei; Chang, Chi-Yen; Kuo, Ching-Chuan; Yeh, Teng-Kuang; Lin, Chin-Yu; Wu, Jian-Sung; Wu, Su-Ying; Liao, Chun-Chen; Hsieh, Hsing-Pang
Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 3076 - 3080
反应条件
1: sodium hydroxide / dichloromethane / 8 h / 20 °C / Inert atmosphere
2: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 40 h / Inert atmosphere; Reflux
View Scheme
参考文献
Tung, Yen-Shih; Coumar, Mohane Selvaraj; Wu, Yu-Shan; Shiao, Hui-Yi; Chang, Jang-Yang; Liou, Jing-Ping; Shukla, Paritosh; Chang, Chun-Wei; Chang, Chi-Yen; Kuo, Ching-Chuan; Yeh, Teng-Kuang; Lin, Chin-Yu; Wu, Jian-Sung; Wu, Su-Ying; Liao, Chun-Chen; Hsieh, Hsing-Pang
Journal of Medicinal Chemistry, 2011 , vol. 54, # 8 p. 3076 - 3080
