1: 3-phenyl-6-methyl pyridine With n-butyllithium in tetrahydrofuran T=-78°C; 0.0833333 h; 2: carbonic acid diethyl ester in tetrahydrofuran T=-78°C; 2 h;

1: 3-phenyl-6-methyl pyridine With lithium hexamethyldisilazane in tetrahydrofuran T=-60°C; 0.5 h; Inert atmosphere; 2: carbonic acid diethyl ester in tetrahydrofuran T=20°C;

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / ethylene glycol dimethyl ether; water / 0.25 h / 140 °C / Inert atmosphere; Microwave irradiation 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere 2.2: 20 °C View Scheme

1: With sodium hydroxide; water in tetrahydrofuran T=35°C; 2: With hydrogenchloride; water