(4-溴-3-氟-苯基)-吗啉-4-基-甲酮合成路线 （共 3 条）
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in N,N-dimethyl acetamide T=80°C; 15 h;
参考文献
WO2008/148867 A2, ;
Page/Page column 28-29 ;
WO 2008/148867 A2
反应条件
in tetrahydrofuran T=0°C; 1 h; Product distribution / selectivity;
参考文献
PFIZER INC.
Patent: WO2009/69044 A1, 2009 ;
Location in patent: Page/Page column 104; 134-135 ;
WO 2009/069044 A1
反应条件
n-ethyl morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide
T=20°C; 18 h;
参考文献
Hangauer, David G.
Patent: US2006/160800 A1, 2006 ;
Location in patent: Page/Page column 84 ;
US 20060160800 A1
