1: pyridine 2: dimethylformamide 3: CH3CO3H, NaHCO3 / CH2Cl2 4: 1.) LDA / 1.) THF, 0 deg C, 15 min 5: pyridine / 23 °C 6: Li, NH3 / tetrahydrofuran / -78 °C 7: 2.) K2CO3 / 1.) 1,2-dichloroethane, 70 deg C, 24 h, 2.) MeOH, 0 deg C 8: 1.) LiN(SiMe3)2 / 1.) dioxane 9: 80percent HOAc 10: Na2CO3, KOH / ethanol; tetrahydrofuran View Scheme