2-氨基-6-氯-吡啶并[3,2-d]嘧啶-4(1h)-酮合成路线 （共 5 条）
反应条件
1: in sulfolane; dimethylsulfone
T=165°C; 0.5 h;
2: With ammonia in water
T=20°C; pH=7; Product distribution / selectivity;
参考文献
4 AZA Bioscience nv
Patent: WO2006/135993 A1, 2006 ;
Location in patent: Page/Page column 48 ;
反应条件
1: With hydrogenchloride; water
5 h; Heating / reflux;
2: With sodium hydroxide in water
pH=9 - 10; Product distribution / selectivity;
参考文献
4 AZA Bioscience nv
Patent: WO2006/135993 A1, 2006 ;
Location in patent: Page/Page column 48; 1/6; 4/6 ;
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water
24 h; Heating / reflux; Product distribution / selectivity;
参考文献
4 AZA Bioscience nv
Patent: WO2006/135993 A1, 2006 ;
Location in patent: Page/Page column 48-49 ;
反应条件
2 h; Heating / reflux;
参考文献
4 AZA Bioscience nv
Patent: WO2006/135993 A1, 2006 ;
Location in patent: Page/Page column 91-92 ;
反应条件
N-ethyl-N,N-diisopropylamine; trichlorophosphate in acetonitrile
T=20°C; 240 h;
参考文献
Herdewijn, Piet Andre' Maurits Maria; De Jonghe, Steven Cesar Alfons; Watkins, William John; Chong, Lee Shun; Zhang, Jennifer
Patent: US2009/253696 A1, 2009 ;
Location in patent: Page/Page column 20 ;
