7-肼基-3,4-二氢-1(2H)-异喹啉酮合成路线 （共 5 条）
反应条件
1: With hydrogenchloride; sodium nitrite in water
T=5°C; 0.5 h;
2: With hydrogenchloride; tin(ll) chloride in water
T=0°C; 2 h;
参考文献
DECIPHERA PHARMACEUTICALS, LLC
Patent: WO2006/71940 A2, 2006 ;
Location in patent: Page/Page column 411 ;
WO 2006/071940 A2
反应条件
1: sodium carbonate / ethyl acetate; water / 2 h / 0 - 20 °C
2: polyphosphoric acid / 2.5 h / 140 - 160 °C
3: sulfuric acid; nitric acid / 2 h / |Cooling with ice
4: hydrogen; palladium 10 on activated carbon / methanol / 20 °C / 2068.65 Torr
5: SnCl2·2H2O; sodium nitrite; hydrogenchloride / water / 2 h / 0 - 5 °C
View Scheme
参考文献
DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel L.; PETILLO, Peter A.; KAUFMAN, Michael D.
Patent: WO2013/36232 A2, 2013 ;
反应条件
1: polyphosphoric acid / 2.5 h / 140 - 160 °C
2: sulfuric acid; nitric acid / 2 h / |Cooling with ice
3: hydrogen; palladium 10 on activated carbon / methanol / 20 °C / 2068.65 Torr
4: SnCl2·2H2O; sodium nitrite; hydrogenchloride / water / 2 h / 0 - 5 °C
View Scheme
参考文献
DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel L.; PETILLO, Peter A.; KAUFMAN, Michael D.
Patent: WO2013/36232 A2, 2013 ;
反应条件
1: sulfuric acid; nitric acid / 2 h / |Cooling with ice
2: hydrogen; palladium 10 on activated carbon / methanol / 20 °C / 2068.65 Torr
3: SnCl2·2H2O; sodium nitrite; hydrogenchloride / water / 2 h / 0 - 5 °C
View Scheme
参考文献
DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel L.; PETILLO, Peter A.; KAUFMAN, Michael D.
Patent: WO2013/36232 A2, 2013 ;
反应条件
1: hydrogen; palladium 10 on activated carbon / methanol / 20 °C / 2068.65 Torr
2: SnCl2·2H2O; sodium nitrite; hydrogenchloride / water / 2 h / 0 - 5 °C
View Scheme
参考文献
DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel L.; PETILLO, Peter A.; KAUFMAN, Michael D.
Patent: WO2013/36232 A2, 2013 ;
