N-[4-[[3-氯-4-[(3-氟苯基)甲氧基]苯基]氨基]-6-喹唑啉]-2-丙酰胺合成路线 （共 5 条）
反应条件
triethylamine in tetrahydrofuran T=0 - 20°C; 3 h;
参考文献
EP1990337 A1, ;
Page/Page column 9 ;
反应条件
1: isopropyl alcohol / 3 h / Reflux 2: acetic acid; iron / methanol / 2.5 h / 85 °C 3: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice View Scheme
反应条件
1: isopropyl alcohol / 3 h / Reflux 2: acetic acid; iron / methanol / 2.5 h / 85 °C 3: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice View Scheme
反应条件
1: acetic acid; iron / methanol / 2.5 h / 85 °C 2: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice View Scheme
反应条件
in tetrahydrofuran; methanol; water Product distribution / selectivity;
参考文献
Guo, Jianhui; Jiang, Yong
Patent: US2012/4249 A1, 2012 ;
Location in patent: Page/Page column 8 ;
