N-(1-羟基-2-萘甲酰基)-2-甲基丙氨酸甲酯合成路线 (共 1 条)
反应条件
1: 1-hydroxy-naphthalene-2-carboxylic acid With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide in N,N-dimethyl-formamide
T=0°C; 0.5 h;
2: methyl 2-amino-2-methylpropionate hydrochloride With N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C; 16 h;
参考文献
Sanofi-Aventis Deutschland GmbH
Patent: EP1676834 A1, 2006 ;
Location in patent: Page/Page column 29 ;
EP 1676834 A1