1.1: potassium hydroxide / water / 3 h / 20 °C / |Large scale 2.1: 4-(N,N-dimethlyamino)pyridine; 1H-imidazole / N,N-dimethyl-formamide / 1 h / |Large scale 2.2: 16 h / 0 - 20 °C / |Inert atmosphere; |Large scale View Scheme

1: 100 percent / NH2NH2*H2O / 6 h / 23 °C 2: 85 percent / CH2Cl2; pyridine / 11 h / 0 - 23 °C 3: 48 percent / toluene / 2 h / 70 °C 4: 80.5 percent / LiAlH4 / tetrahydrofuran / 2 h / 0 °C 5: 91 percent / pyridine / CH2Cl2 / 6 h / -60 °C 6: 99 percent / pyridine / CH2Cl2 / 5 h / 0 - 23 °C 7: 94 percent / 15-crown-15 / tetrahydrofuran / 2 h / 23 °C 8: 99 percent / TBAF / tetrahydrofuran / 2.5 h / -30 °C 9: 100 percent / DBU / CH2Cl2 / 1 h / 23 °C 10: 33 percent / EtN(i-Pr)2 / xylene / 24 h / 110 °C 11: 93 percent / HCl; water / methanol / 3 h / 23 °C View Scheme

potassium hydroxide 3 h; Ambient temperature;