8-氧代-5,6,7,8-四氢萘-2-羧酸合成路线 （共 12 条）
反应条件
1: 7-Bromo-1,2,3,4-tetrahydronaphthalene-1-spiro-2'-(1',3'-dioxacyclopentane) With tert.-butyl lithium in tetrahydrofuran; pentane T=-78 - 0°C; 2: carbon dioxide in tetrahydrofuran; pentane T=-78°C; 0.5 h; 3: With hydrogenchloride; water in tetrahydrofuran; pentane T=-78°C;
参考文献
Chen, Wen-Ching; Lee, Yi-Wei; Chen, Chien-Tien
Organic Letters, 2010 , vol. 12, # 7 p. 1472 - 1475
反应条件
aluminium trichloride; sodium chloride
参考文献
Journal of the Chemical Society, , p. 4647,3652
反应条件
1: AlCl3 2: NaOCl, OH- 3: AlCl3, NaCl / Heating View Scheme
参考文献
Farmaco, , vol. 46, # SUPPL. 1 p. 209 - 231
反应条件
1: NaOCl, OH- 2: AlCl3, NaCl / Heating View Scheme
参考文献
Farmaco, , vol. 46, # SUPPL. 1 p. 209 - 231
反应条件
1: NaClO 2: AlCl3; NaCl View Scheme
参考文献
Journal of the Chemical Society, , p. 4647,3652
反应条件
hydroxylamine in methanol Heating;
参考文献
Ernest; Kalvoda; Rihs; Mutter
Tetrahedron Letters, 1990 , vol. 31, # 28 p. 4011 - 4014
反应条件
1: 83.4 percent / NH2OH / methanol / 2 h / 60 °C 2: 87.2 percent / H2 / 5percent Pd/C / methanol / 5 h / 25 °C / 3000.2 Torr 3: 83.4 percent / 1M aq. Na2CO3 / dioxane / Ambient temperature View Scheme
参考文献
Ernest, Ivan; Kalvoda, Jaroslav; Sigel, Christoph; Rihs, Grety; Fritz, Hans; et al.
Helvetica Chimica Acta, 1993 , vol. 76, # 4 p. 1539 - 1563
反应条件
thionyl chloride T=20°C; 12 h;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2005/12280 A1, 2005 ;
Location in patent: Page/Page column 55 ;
WO 2005/012280 A1
反应条件
in methanol; hexane; ethyl acetate
参考文献
The Dupont Merck Pharmaceutical Company
Patent: US5879657 A1, 1999 ;
反应条件
in methanol; diethyl ether
参考文献
Ernest, Ivan; Kalvoda, Jaroslav; Sigel, Christoph; Rihs, Grety; Fritz, Hans; et al.
Helvetica Chimica Acta, 1993 , vol. 76, # 4 p. 1539 - 1563
