1-(3,4-二氢-2-萘)-1H-咪唑合成路线 （共 4 条）
反应条件
sulfuric acid; acetic acid
T=100°C; 4 h;
参考文献
Voets, Marieke; Antes, Iris; Scherer, Christiane; Mueller-Vieira, Ursula; Biemel, Klaus; Marchais-Oberwinkler, Sandrine; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2222 - 2231
反应条件
1: 65 percent / dimethylformamide / 20 °C
2: 91 percent / NaBH4 / methanol / 1 h / 20 °C
3: 96 percent / acetic acid; sulfuric acid / 4 h / 100 °C
View Scheme
参考文献
Voets, Marieke; Antes, Iris; Scherer, Christiane; Mueller-Vieira, Ursula; Biemel, Klaus; Marchais-Oberwinkler, Sandrine; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2222 - 2231
反应条件
1: 91 percent / NaBH4 / methanol / 1 h / 20 °C
2: 96 percent / acetic acid; sulfuric acid / 4 h / 100 °C
View Scheme
参考文献
Voets, Marieke; Antes, Iris; Scherer, Christiane; Mueller-Vieira, Ursula; Biemel, Klaus; Marchais-Oberwinkler, Sandrine; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2222 - 2231
反应条件
1: 50 percent / tetrabutylammonium tribromide / methanol; CH2Cl2 / 20 °C
2: 65 percent / dimethylformamide / 20 °C
3: 91 percent / NaBH4 / methanol / 1 h / 20 °C
4: 96 percent / acetic acid; sulfuric acid / 4 h / 100 °C
View Scheme
参考文献
Voets, Marieke; Antes, Iris; Scherer, Christiane; Mueller-Vieira, Ursula; Biemel, Klaus; Marchais-Oberwinkler, Sandrine; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2222 - 2231
