2-氨基-3-硝基-4,6-二甲基-5-溴吡啶合成路线 （共 9 条）
反应条件
ammonium hydroxide; hydrogen; palladium on activated charcoal in methanol T=50°C; P=2585.74 Torr; 18 h;
参考文献
Tanga; Bradford; Bupp; Kozocas
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 4 p. 569 - 573
反应条件
1: 85 percent / ammonium formate, 10percent Pd/C / methanol / 4 h / Heating 2: 69 percent / polyphosphoric acid / 5 h / 100 °C View Scheme
参考文献
Heitsch, Holger; Becker, Reinhard H.A.; Kleemann, Heinz-Werner; Wagner, Adalbert
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 4 p. 673 - 678
反应条件
1: SnCl2; aqueous HCl 3: palladium/charcoal; platinum; aq. NaOH solution / Hydrogenation View Scheme
参考文献
Graboyes; Day
Journal of the American Chemical Society, 1957 , vol. 79, p. 6421,6423,6424
反应条件
1: SnCl2; aqueous HCl 2: aqueous H2SO4; KNO2 View Scheme
参考文献
Graboyes; Day
Journal of the American Chemical Society, 1957 , vol. 79, p. 6421,6423,6424
反应条件
1: SnCl2; aqueous HCl 2: aqueous H2SO4; KNO2 3: palladium/charcoal; platinum; aq. NaOH solution / Hydrogenation View Scheme
参考文献
Graboyes; Day
Journal of the American Chemical Society, 1957 , vol. 79, p. 6421,6423,6424
反应条件
sulfuric acid; nitric acid
T=-10 - 20°C; 0.5 h;
参考文献
Heitsch, Holger; Becker, Reinhard H.A.; Kleemann, Heinz-Werner; Wagner, Adalbert
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 4 p. 673 - 678
反应条件
1: 59 percent / bromine; glacial acetic acid / 1.33 h / 20 °C
2: 64 percent / potassium nitrate; concd. sulfuric acid / 1 h / 20 °C
View Scheme
参考文献
Tanga; Bradford; Bupp; Kozocas
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 4 p. 569 - 573
反应条件
1: SnCl2; aqueous HCl
View Scheme
参考文献
Graboyes; Day
Journal of the American Chemical Society, 1957 , vol. 79, p. 6421,6423,6424
反应条件
1: 98 percent / hydrogen; ammonium hydroxide / palladium on carbon / methanol / 18 h / 50 °C / 2585.74 Torr
2: 49 percent / potassium carbonate / acetone / 18 h / 20 °C
3: lithium aluminum hydride / tetrahydrofuran / 1 h / Heating
4: 75 mg / methanol / 6 h / 120 °C
View Scheme
参考文献
Tanga; Bradford; Bupp; Kozocas
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 4 p. 569 - 573
