2-氯嘧啶-5-羧酸乙酯合成路线 （共 17 条）
反应条件
1: With trichlorophosphate in N,N-dimethyl-aniline 1.5 h; Heating / reflux; 2: With sodium hydroxide; water T=0°C;
参考文献
CURIS, INC.
Patent: WO2009/36016 A1, 2009 ;
Location in patent: Page/Page column 69 ;
反应条件
1.1: Na; EtOH / benzene / 2 h / 0 °C 1.2: 58 percent / benzene / 3 h / 50 °C 2.1: 66 percent / aq. HCl / ethanol / Heating 3.1: Br2; AcOH / 1.5 h / Heating 4.1: POCl3; N,N-dimethylaniline / 1.5 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 10 p. 1504 - 1513
反应条件
1: Br2; AcOH / 1.5 h / Heating 2: POCl3; N,N-dimethylaniline / 1.5 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 10 p. 1504 - 1513
反应条件
1: aqueous ethanol; zinc-powder 2: H2O; chlorine View Scheme
参考文献
Journal of the American Chemical Society, , vol. 64, p. 794,797
参考文献
Journal of the American Chemical Society, , vol. 64, p. 794,797
反应条件
1: 66 percent / aq. HCl / ethanol / Heating 2: Br2; AcOH / 1.5 h / Heating 3: POCl3; N,N-dimethylaniline / 1.5 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 10 p. 1504 - 1513
反应条件
1: Heating 2: NaOEt / ethanol / 20 °C 3: POCl3 / 3 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 18 p. 2573 - 2577
反应条件
1.1: hydrogenchloride / ethanol; water / Reflux 2.1: bromine; acetic acid / 1.5 h / Reflux 3.1: trichlorophosphate; N,N-dimethyl-aniline / 1.5 h / Reflux 3.2: Cooling with ice View Scheme
参考文献
WO2011/130628 A1, ;
WO 2011/130628 A1
反应条件
1.1: hydrogenchloride / ethanol; water / 2 h / 30 °C / Reflux 2.1: bromine; acetic acid / 15 h / 20 - 110 °C 2.2: 2 h / pH 4 3.1: trichlorophosphate / 2 h / 117 °C / Cooling with ice View Scheme
反应条件
1.1: sodium hydroxide; water / tetrahydrofuran / 1.5 h 1.2: 1 h / pH 1.5 - 4 2.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Leclerc, Jean-Philippe; Li, Chun Sing; Ramtohul, Yeeman K.
Patent: US2011/152295 A1, 2011 ;
