(AR)-4-C氯-A-甲基-2-硝基苯甲胺合成路线 （共 5 条）
反应条件
hydrazine in tetrahydrofuran
T=80°C; 1 h;
参考文献
Marugan, Juan Jose; Leonard, Kristi; Raboisson, Pierre; Gushue, Joan M.; Calvo, Raul; Koblish, Holly K.; Lattanze, Jennifer; Zhao, Shuyuan; Cummings, Maxwell D.; Player, Mark R.; Schubert, Carsten; Maroney, Anna C.; Lu, Tianbao
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 12 p. 3115 - 3120
反应条件
1: NEt3 / CH2Cl2 / 16 h
2: 93 percent / LiOH / methanol; H2O / 16 h
3: 87 percent / Ph3P; DIAD / tetrahydrofuran / 3 h / 20 °C
4: 96 percent / hydrazine / tetrahydrofuran / 1 h / 80 °C
View Scheme
参考文献
Marugan, Juan Jose; Leonard, Kristi; Raboisson, Pierre; Gushue, Joan M.; Calvo, Raul; Koblish, Holly K.; Lattanze, Jennifer; Zhao, Shuyuan; Cummings, Maxwell D.; Player, Mark R.; Schubert, Carsten; Maroney, Anna C.; Lu, Tianbao
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 12 p. 3115 - 3120
反应条件
1: 87 percent / Ph3P; DIAD / tetrahydrofuran / 3 h / 20 °C
2: 96 percent / hydrazine / tetrahydrofuran / 1 h / 80 °C
View Scheme
参考文献
Marugan, Juan Jose; Leonard, Kristi; Raboisson, Pierre; Gushue, Joan M.; Calvo, Raul; Koblish, Holly K.; Lattanze, Jennifer; Zhao, Shuyuan; Cummings, Maxwell D.; Player, Mark R.; Schubert, Carsten; Maroney, Anna C.; Lu, Tianbao
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 12 p. 3115 - 3120
反应条件
1: 93 percent / LiOH / methanol; H2O / 16 h
2: 87 percent / Ph3P; DIAD / tetrahydrofuran / 3 h / 20 °C
3: 96 percent / hydrazine / tetrahydrofuran / 1 h / 80 °C
View Scheme
参考文献
Marugan, Juan Jose; Leonard, Kristi; Raboisson, Pierre; Gushue, Joan M.; Calvo, Raul; Koblish, Holly K.; Lattanze, Jennifer; Zhao, Shuyuan; Cummings, Maxwell D.; Player, Mark R.; Schubert, Carsten; Maroney, Anna C.; Lu, Tianbao
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 12 p. 3115 - 3120
反应条件
1: 73 percent / tetrahydrofuran / 0.5 h / -78 - 20 °C
2: NEt3 / CH2Cl2 / 16 h
3: 93 percent / LiOH / methanol; H2O / 16 h
4: 87 percent / Ph3P; DIAD / tetrahydrofuran / 3 h / 20 °C
5: 96 percent / hydrazine / tetrahydrofuran / 1 h / 80 °C
View Scheme
参考文献
Marugan, Juan Jose; Leonard, Kristi; Raboisson, Pierre; Gushue, Joan M.; Calvo, Raul; Koblish, Holly K.; Lattanze, Jennifer; Zhao, Shuyuan; Cummings, Maxwell D.; Player, Mark R.; Schubert, Carsten; Maroney, Anna C.; Lu, Tianbao
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 12 p. 3115 - 3120
