3-甲基-1,3-氮杂环丁烷二羧酸 1-叔丁酯 3-甲酯合成路线 （共 3 条）
反应条件
lithium borohydride in tetrahydrofuran T=20°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ECKHARDT, Matthias; FRATTINI, Sara; HAMPRECHT, Dieter; HIMMELSBACH, Frank; LANGKOPF, Elke; LINGARD, Iain; PETERS, Stefan; WAGNER, Holger
Patent: WO2013/144097 A1, 2013 ;
Location in patent: Page/Page column 100 ;
反应条件
1: 1-BOC-3-methylazetidine-3-carboxylic acid With n-butyllithium; diisopropylamine in tetrahydrofuran
T=-78 - 0°C; 3.5 h;
2: methyl iodide in tetrahydrofuran
T=-78 - 20°C; 2 h;
参考文献
ASTRAZENECA AB
Patent: WO2006/73361 A1, 2006 ;
Location in patent: Page/Page column 171-172 ;
WO 2006/073361 A1
反应条件
in diethyl ether; dichloromethane
T=0°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FADER, Lee; BEAULIEU, Pierre Louis; BAILEY, Murray; BILODEAU, François; CARSON, Rebekah; GIROUX, André; GODBOUT, Cédrickx; HUCKE, Oliver; JOLY, Marc-André; LEBLANC, Mélissa; LEPAGE, Olivier; MOREAU, Benoît; NAUD, Julie; POIRIER, Martin; VILLEMURE, Elisia
Patent: WO2013/152065 A2, 2013 ;
Location in patent: Page/Page column 31 ;
