2-hydroxy-1,3-dimethylbenzene; D-glucose-derived ligand; Gd*D-glucose-derived ligand in various solvent(s) T=-40°C; Strecker reaction; 1 h;

chiral bis(piperidinecarboxamide) derivative; 3-chloro-benzenecarboperoxoic acid in toluene T=-20°C; Strecker reaction; 196 h; Title compound not separated from byproducts;

trimethylsilyl cyanide; Gd(iPr)3; 1,5-anhydro-2,6-dideoxy-3-O-(4,5-difluoro-2-hydroxyphenyl)-6-(diphenylphosphinyl)-D-arabino-hexitol in various solvent(s) T=-40°C; Strecker reaction; 19 h; Title compound not separated from byproducts.;

1: triethylamine / petroleum ether; CH2Cl2 / -45 - -40 °C 2: chiral bis(piperidinecarboxamide) derivative; m-chloroperoxybenzoic acid / toluene / 196 h / -20 °C View Scheme

1: NH2OH*HCl; NaOAc / ethanol; H2O / Heating 2: triethylamine / petroleum ether; CH2Cl2 / -45 - -40 °C 3: chiral bis(piperidinecarboxamide) derivative; m-chloroperoxybenzoic acid / toluene / 196 h / -20 °C View Scheme

zirconium tetra-t-butoxide; (1S,8R,9S,1'S,8'R,9'S)-[8'-(hydroxy-diphenyl-methyl)-10,10,10',10'-tetramethyl-[5,5']bi[6-aza-tricyclo[7.1.1.02,7]undecyl]-2(7),3,5,2',4',6'-hexaen-8-yl]-diphenyl-methanol in toluene T=0°C; Strecker type reaction; 40 h; optical yield given as percent eeenantioselective reaction;

PBAP; (S)-BINOL-phosphoric acid; sodium hydride in toluene T=-20°C; Strecker reaction; 96 h; Inert atmosphere; optical yield given as percent ee;