2-(4-氨基-1-哌啶)乙醇合成路线 （共 4 条）
反应条件
1: With hydrogen; sodium; rhodium contaminated with carbon in methanol
T=60°C; P=7240.26 Torr;
2: in methanol
Reflux;
参考文献
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION; YANG, Qi; JAMES, Susan N.; BALLARD, Mathew John; BOWN, Mark; FERON, Paul; PUXTY, Graeme Douglas
Patent: WO2012/142668 A1, 2012 ;
Location in patent: Page/Page column 48; 49 ;
反应条件
trifluoroacetic acid
T=20°C; 1 h;
参考文献
Pham, Tien Q.; Greguric, Ivan; Liu, Xiang; Berghofer, Paula; Ballantyne, Patrice; Chapman, Janette; Mattner, Filomena; Dikic, Branko; Jackson, Timothy; Loc'h, Christian; Katsifis, Andrew
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3561 - 3572
反应条件
1: 94 percent / K2CO3 / acetonitrile / 5 h / Heating
2: 95 percent / TFA / 1 h / 20 °C
View Scheme
参考文献
Pham, Tien Q.; Greguric, Ivan; Liu, Xiang; Berghofer, Paula; Ballantyne, Patrice; Chapman, Janette; Mattner, Filomena; Dikic, Branko; Jackson, Timothy; Loc'h, Christian; Katsifis, Andrew
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3561 - 3572
反应条件
1.1: toluene / 3.5 h / Reflux
2.1: hydrogen; sodium / rhodium contaminated with carbon / methanol / 60 °C / 7240.26 Torr
2.2: Amberlyst 15 resin / Reflux
View Scheme
参考文献
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION; YANG, Qi; JAMES, Susan N.; BALLARD, Mathew John; BOWN, Mark; FERON, Paul; PUXTY, Graeme Douglas
Patent: WO2012/142668 A1, 2012 ;
