反应条件
1.1: HOBt; HBTU; DIPEA / dimethylformamide / 0.25 h / 0 °C 1.2: 98 percent / dimethylformamide / 2 h / 0 - 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / -78 °C 2.2: tetrahydrofuran; hexane / 2 h / -78 - -35 °C 3.1: m-CPBA / CHCl3 / 1 h / -15 °C 3.2: propan-2-ol / 1 h / 100 - 110 °C / microwave irradiation View Scheme
参考文献
Chu, Xin-Jie; DePinto, Wanda; Bartkovitz, David; So, Sung-Sau; Vu, Binh T.; Packman, Kathryn; Lukacs, Christine; Ding, Qingjie; Jiang, Nan; Wang, Ka; Goelzer, Petra; Yin, Xuefeng; Smith, Melissa A.; Higgins, Brian X.; Chen, Yingsi; Xiang, Qing; Moliterni, John; Kaplan, Gerald; Graves, Bradford; Lovey, Allen; Fotouhi, Nader
Journal of Medicinal Chemistry, 2006 , vol. 49, # 22 p. 6549 - 6560