反应条件
1.1: potassium carbonate / acetone / 22 h / 60 °C / Inert atmosphere
2.1: water; sodium hydroxide / tetrahydrofuran; methanol; dichloromethane / 20 °C
3.1: thionyl chloride / chloroform / Inert atmosphere
4.1: triethylamine / dichloromethane
5.1: lithium diisopropyl amide / tetrahydrofuran / Cooling with ice
5.2: -78 °C
6.1: 1 h / Reflux
7.1: hydrazine hydrate / methanol / 1 h / Reflux
8.1: sulfuric acid / ethanol / 1 h / Reflux
View Scheme
参考文献
Tu, Zhude; Fan, Jinda; Li, Shihong; Jones, Lynne A.; Cui, Jinquan; Padakanti, Prashanth K.; Xu, Jinbin; Zeng, Dexing; Shoghi, Kooresh I.; Perlmutter, Joel S.; MacH, Robert H.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1666 - 1673