2-(4-氟苯基)-5-[(5-碘-2-甲基苯基)甲基]噻吩合成路线 （共 4 条）
反应条件
sodium iodide; N-methyl-2-(methylamino)ethylamine; copper(l) iodide in diethylene glycol dimethyl ether; toluene T=110°C;
参考文献
WO2009/35969 A1, ;
Page/Page column 77 ;
WO 2009/035969 A1
反应条件
1: 5-iodo-2-methylbenzoic acid chloride With AlCl3, aluminium chloride in dichloromethane T=2°C; 0.25 h; 2: 2-(4-fluorophenyl)-thiophene in dichloromethane T=2 - 20°C; 2.41667 h; Product distribution / selectivity;
参考文献
US2010/99883 A1, ;
Page/Page column 40-41 ;
US 20100099883 A1
反应条件
1.1: n-butyllithium; zinc dibromide / n-heptane; toluene; anhydrous butyl ether / 2.5 h / -10 - 25 °C / Inert atmosphere 1.2: 6.5 h / 95 °C 2.1: methanol / sodium methylate / 16 h / 60 °C View Scheme
参考文献
JANSSEN PHARMACEUTICA NV; HOUPIS, Ioannis, Nicolaos; LEMAIRE, Sebastien, Francois, Emmanuel
Patent: WO2012/140120 A1, 2012 ;
WO 2012/140120 A1
反应条件
1.1: (trimethyl)silylmethyllithium / toluene; diethyl ether; pentane / 0.75 h / -50 °C / Inert atmosphere 1.2: 1 h / 25 °C 2.1: ethyl acetate; toluene / 21 h / 75 °C / Inert atmosphere 3.1: methanol / 16 h / 20 - 60 °C 4.1: water / 1 h / 0 °C View Scheme
参考文献
FARINA, Vittorio; Lemaire, Sebastien François Emmanuel; Houpis, Ioannis N.
Patent: US2011/87017 A1, 2011 ;
