2,3-二氢-1-吲哚羧酸甲酯合成路线 （共 17 条）
反应条件
copper(l) iodide; caesium carbonate; N-methyl-2-(methylamino)ethylamine in tetrahydrofuran
T=80°C; 16 h; Inert atmosphere;
参考文献
Minatti, Ana; Buchwald, Stephen L.
Organic Letters, 2008 , vol. 10, # 13 p. 2721 - 2724
反应条件
tris(dibenzylideneacetone)dipalladium (0); caesium carbonate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane
T=110°C; Buchwald amidation; 46 h;
参考文献
Ganton, Michael D.; Kerr, Michael A.
Organic Letters, 2005 , vol. 7, # 21 p. 4777 - 4779
反应条件
pyridine in dichloromethane
T=0 - 20°C; 1 h; Inert atmosphere;
参考文献
Chelucci, Giorgio; Pinna, Gerard A.; Pinna, Giansalvo
European Journal of Organic Chemistry, 2014 , vol. 2014, # 18 p. 3802 - 3807
反应条件
palladium diacetate; caesium carbonate; PCy3∙HBF4; 2,2,2-trimethylacetic acid in anhydrous xylene
T=140°C; 24 h; Inert atmosphere;
参考文献
Watanabe, Toshiaki; Oishi, Shinya; Fujii, Nobutaka; Ohno, Hiroaki
Organic Letters, 2008 , vol. 10, # 9 p. 1759 - 1762
反应条件
in various solvent(s)
T=230°C; 12 h;
参考文献
Boger, Dale L.; Coleman, Robert S.
Journal of Organic Chemistry, 1984 , vol. 49, # 12 p. 2240 - 2245
反应条件
sodium chloride in pyridine; 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran
参考文献
Sanofi
Patent: US5594023 A1, 1997 ;
反应条件
in methanol; benzene
T=20°C; atmospheric pressure;
参考文献
Ito, Yoshikatsu; Ushitora, Hiromi
Tetrahedron, 2006 , vol. 62, # 1 p. 226 - 235
反应条件
potassium tert-butylate
T=90°C; 6 h; Inert atmosphere;
参考文献
Arico, Fabio; Toniolo, Umberto; Tundo, Pietro
Green Chemistry, 2012 , vol. 14, # 1 p. 58 - 61
反应条件
1: NaBH4 / tetrahydrofuran; methanol / 0.33 h / 0 °C
2: 1.84 g / pyridine / CH2Cl2 / 12 h / 0 - 20 °C
3: 71 percent / Pd2(dba)3; Cs2CO3; XANTPHOS / dioxane / 46 h / 110 °C
View Scheme
参考文献
Ganton, Michael D.; Kerr, Michael A.
Organic Letters, 2005 , vol. 7, # 21 p. 4777 - 4779
反应条件
1: 1.84 g / pyridine / CH2Cl2 / 12 h / 0 - 20 °C
2: 71 percent / Pd2(dba)3; Cs2CO3; XANTPHOS / dioxane / 46 h / 110 °C
View Scheme
参考文献
Ganton, Michael D.; Kerr, Michael A.
Organic Letters, 2005 , vol. 7, # 21 p. 4777 - 4779
