4-(4-溴-2-甲基苯基)-4-氧代丁酸合成路线 （共 2 条）
反应条件
1: With AlCl3, aluminium chloride T=-5 - 20°C; 2: With hydrogenchloride in water T=0 - 20°C; 0.5 h;
参考文献
Allan, Gillian M.; Vicker, Nigel; Lawrence, Harshani R.; Tutill, Helena J.; Day, Joanna M.; Huchet, Marion; Ferrandis, Eric; Reed, Michael J.; Purohit, Atul; Potter, Barry V.L.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 8 p. 4438 - 4456
反应条件
1: 4-bromo-1-iodo-2-methylbenzene With iso-propylmagnesium bromide in tetrahydrofuran T=-25°C; 3 h; 2: succinic acid anhydride in tetrahydrofuran 18 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2007/76431 A1, 2007 ;
Location in patent: Page/Page column 192 ;
WO 2007/076431 A1
