3-(2-吡啶基羰基)苯甲腈合成路线 （共 4 条）
反应条件
copper(l) iodide; oxygen; acetic acid in dimethyl sulfoxide
T=100°C; 24 h;
参考文献
De Houwer, Johan; Abbaspour Tehrani, Kourosch; Maes, Bert U. W.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2745 - 2748
反应条件
in tetrahydrofuran
T=20°C; 1 h; Inert atmosphere;
参考文献
Kim, Seung-Hoi; Rieke, Reuben D.
Tetrahedron, 2010 , vol. 66, # 17 p. 3135 - 3146
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - -50 °C / Inert atmosphere
1.2: 2 h / -50 °C / Inert atmosphere
1.3: Inert atmosphere
2.1: palladium (II) trifluoroacetate; caesium carbonate; tri-cyclo-hexyl-phosphine / o-xylene; toluene / 6 h / Inert atmosphere; Reflux
3.1: copper(l) iodide; oxygen; acetic acid / dimethyl sulfoxide / 24 h / 100 °C
View Scheme
参考文献
De Houwer, Johan; Abbaspour Tehrani, Kourosch; Maes, Bert U. W.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2745 - 2748
反应条件
1: palladium (II) trifluoroacetate; caesium carbonate; tri-cyclo-hexyl-phosphine / o-xylene; toluene / 6 h / Inert atmosphere; Reflux
2: copper(l) iodide; oxygen; acetic acid / dimethyl sulfoxide / 24 h / 100 °C
View Scheme
参考文献
De Houwer, Johan; Abbaspour Tehrani, Kourosch; Maes, Bert U. W.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2745 - 2748
