乙基5-(4-溴苯基)-5-氧代戊酸酯合成路线 （共 5 条）
反应条件
aluminium trichloride T=20°C; Friedel-Crafts reaction; 3.5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 10 p. 2049 - 2063
反应条件
1: 2 N aq. NaOH / methanol / 1.5 h / Heating 2: 73 percent / triethylsilane; TFA / 48 h / 55 °C View Scheme
参考文献
Shiraishi, Mitsuru; Aramaki, Yoshio; Seto, Masaki; Imoto, Hiroshi; Nishikawa, Youichi; Kanzaki, Naoyuki; Okamoto, Mika; Sawada, Hidekazu; Nishimura, Osamu; Baba, Masanori; Fujino, Masahiko
Journal of Medicinal Chemistry, 2000 , vol. 43, # 10 p. 2049 - 2063
反应条件
sodium hydroxide in methanol Hydrolysis; 1.5 h; Heating;
参考文献
TEIJIN PHARMA LIMITED
Patent: US2012/46467 A1, 2012 ;
Location in patent: Page/Page column 24 ;
反应条件
1: 2 N aq. NaOH / methanol / 1.5 h / Heating
2: 73 percent / triethylsilane; TFA / 48 h / 55 °C
3: 67 percent / polyphosphoric acid / 12 h / 100 °C
View Scheme
参考文献
Shiraishi, Mitsuru; Aramaki, Yoshio; Seto, Masaki; Imoto, Hiroshi; Nishikawa, Youichi; Kanzaki, Naoyuki; Okamoto, Mika; Sawada, Hidekazu; Nishimura, Osamu; Baba, Masanori; Fujino, Masahiko
Journal of Medicinal Chemistry, 2000 , vol. 43, # 10 p. 2049 - 2063
反应条件
1: 2 N aq. NaOH / methanol / 1.5 h / Heating
2: 73 percent / triethylsilane; TFA / 48 h / 55 °C
3: 67 percent / polyphosphoric acid / 12 h / 100 °C
4: 98 percent / tetrakis(triphenylphosphine)palladium; 2 M aq. K2CO3 / ethanol; toluene / Heating
View Scheme
参考文献
Shiraishi, Mitsuru; Aramaki, Yoshio; Seto, Masaki; Imoto, Hiroshi; Nishikawa, Youichi; Kanzaki, Naoyuki; Okamoto, Mika; Sawada, Hidekazu; Nishimura, Osamu; Baba, Masanori; Fujino, Masahiko
Journal of Medicinal Chemistry, 2000 , vol. 43, # 10 p. 2049 - 2063
