反应条件
1: 2-Bromo-pyridine-5-carboxaldehyde With tetrakis(triphenylphosphine) palladium(0); potassium carbonate in tetrahydrofuran; water
T=20°C; Inert atmosphere;
2: 2,4-difluoro-phenylboronic acid in tetrahydrofuran; water
T=80°C; Inert atmosphere;
参考文献
Leung, Suet C.; Gibbons, Peter; Amewu, Richard; Nixon, Gemma L.; Pidathala, Chandrakala; Hong, W. David; Pacorel, Benedicte; Berry, Neil G.; Sharma, Raman; Stocks, Paul A.; Srivastava, Abhishek; Shone, Alison E.; Charoensutthivarakul, Sitthivut; Taylor, Lee; Berger, Olivier; Mbekeani, Alison; Hill, Alasdair; Fisher, Nicholas E.; Warman, Ashley J.; Biagini, Giancarlo A.; Ward, Stephen A.; O'Neill, Paul M.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 1844 - 1857