1: 1.) BBr3; 2.) MeOH, H2SO4 (96percent) / 1.) CH2Cl2, room temp., 140 h; 2.) reflux, 48 h 2: 93 percent / benzoyl t-butyl nitroxide / methanol; CHCl3 / 16 h / Ambient temperature View Scheme

1: 21 percent / BBr3 / CH2Cl2 2: 93 percent / tBuN(O)COPh / CH2Cl2; methanol View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: xylene / Heating<br />2: HCl / methanol / Heating<br />3: CH₂Cl₂ <br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: NaOMe / methanol / -10 &deg;C<br />2: xylene / Heating<br />3: HCl / methanol / Heating<br />4: CH₂Cl₂ <br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 80 percent / manganese (IV) oxide / CHCl₃; methanol / 20 h / Ambient temperature<br />2: 73 percent / NaOMe / methanol / 2 h / -15 &deg;C<br />3: 87 percent / xylene / 4 h / Heating<br />4: 85 percent / HCl / methanol / 6 h / Heating<br />5: 2.) HCl / 1.) CH₂Cl₂, room temp., 12 h; 2.) 12 h, ether<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098214', constants.ctx, '0')">hydrogenchloride</a> <br />&nbsp;1.) CH₂Cl₂, room temp., 12 h; 2.) 12 h, ether;&nbsp;&nbsp;Yield given. Multistep reaction;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 7 steps<br /> </b>1: 97 percent / potassium carbonate / acetone / 8 h / Heating<br />2: 98 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 &deg;C<br />3: 80 percent / manganese (IV) oxide / CHCl₃; methanol / 20 h / Ambient temperature<br />4: 73 percent / NaOMe / methanol / 2 h / -15 &deg;C<br />5: 87 percent / xylene / 4 h / Heating<br />6: 85 percent / HCl / methanol / 6 h / Heating<br />7: 2.) HCl / 1.) CH₂Cl₂, room temp., 12 h; 2.) 12 h, ether<br /> <br /> &nbsp;

<b>Multi-step reaction with 9 steps<br /> </b>1: 88 percent / cc. H₂SO₄ / 20 h / Heating<br />2: 94 percent / ethanol / 3.5 h / 45 &deg;C<br />3: 97 percent / potassium carbonate / acetone / 8 h / Heating<br />4: 98 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 &deg;C<br />5: 80 percent / manganese (IV) oxide / CHCl₃; methanol / 20 h / Ambient temperature<br />6: 73 percent / NaOMe / methanol / 2 h / -15 &deg;C<br />7: 87 percent / xylene / 4 h / Heating<br />8: 85 percent / HCl / methanol / 6 h / Heating<br />9: 2.) HCl / 1.) CH₂Cl₂, room temp., 12 h; 2.) 12 h, ether<br /> <br /> &nbsp;