8-氟-3,4,-二氢-2H-苯并[1,4]恶嗪盐酸盐合成路线 （共 3 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C;
参考文献
SENEXIS LIMITED; HORWELL, David Christopher; SCOPES, David Ian Carter
Patent: WO2011/144578 A1, 2011 ;
Location in patent: Page/Page column 30 ;
反应条件
1.1: potassium carbonate / acetone / 3 h / 65 °C
2.1: acetic acid; iron / 20 °C
2.2: pH 7
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
SENEXIS LIMITED; HORWELL, David Christopher; SCOPES, David Ian Carter
Patent: WO2011/144578 A1, 2011 ;
反应条件
1.1: acetic acid; iron / 20 °C
1.2: pH 7
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
SENEXIS LIMITED; HORWELL, David Christopher; SCOPES, David Ian Carter
Patent: WO2011/144578 A1, 2011 ;
