5-(4-溴苯基)-1,2,4-噁二唑合成路线 （共 4 条）
反应条件
hydroxylamine hydrochloride; sodium hydroxide in 1,4-dioxane; acetic acid
T=20 - 80°C; 1 h;
参考文献
MERCK SHARP and DOHME CORP.; MCCOMAS, Casey, C.; KUDUK, Scott, D.; REGER, Thomas, S.
Patent: WO2014/81619 A1, 2014 ;
Location in patent: Page/Page column 44 ;
反应条件
1: thionyl chloride / 2 h / |Reflux
2: ammonium hydroxide / dichloromethane / 1 h / 0 - 20 °C
3: 2 h / 80 °C
4: hydroxylamine hydrochloride; sodium hydroxide / 1,4-dioxane; acetic acid / 1 h / 20 - 80 °C
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; MCCOMAS, Casey, C.; KUDUK, Scott, D.; REGER, Thomas, S.
Patent: WO2014/81619 A1, 2014 ;
反应条件
1: ammonium hydroxide / dichloromethane / 1 h / 0 - 20 °C
2: 2 h / 80 °C
3: hydroxylamine hydrochloride; sodium hydroxide / 1,4-dioxane; acetic acid / 1 h / 20 - 80 °C
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; MCCOMAS, Casey, C.; KUDUK, Scott, D.; REGER, Thomas, S.
Patent: WO2014/81619 A1, 2014 ;
反应条件
1: 2 h / 80 °C
2: hydroxylamine hydrochloride; sodium hydroxide / 1,4-dioxane; acetic acid / 1 h / 20 - 80 °C
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; MCCOMAS, Casey, C.; KUDUK, Scott, D.; REGER, Thomas, S.
Patent: WO2014/81619 A1, 2014 ;
