1-(4-哌啶基)乙酮盐酸盐合成路线 （共 4 条）
参考文献
MERCK and CO., INC.
Patent: EP863757 B1, 2003 ;
反应条件
hydrogenchloride in 1,4-dioxane; dichloromethane
T=0°C; 2 h;
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
Location in patent: Page/Page column 192 ;
反应条件
1: HATU; triethylamine / dichloromethane / 20 °C
2: tetrahydrofuran / 0 - 20 °C
3: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 0 °C
View Scheme
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
反应条件
1: tetrahydrofuran / 0 - 20 °C
2: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 0 °C
View Scheme
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
