4-氰基-[1,1-联苯]-4-羧酸甲酯合成路线 （共 15 条）
反应条件
Pd-PEPPSI-IPr in tetrahydrofuran T=25°C; Negishi Coupling Reaction; 2 h;
参考文献
LUDWIG-MAXIMILIANS-UNIVERSITAeT MUeNCHEN; KNOCHEL, Paul; BERNHARDT, Sebastian; MANOLIKAKES, Georg
Patent: WO2012/85168 A1, 2012 ;
Location in patent: Page/Page column 29; 31 ;
反应条件
1: para-bromobenzonitrile With diisobutylaluminium hydride; magnesium; lithium chloride in tetrahydrofuran T=25°C; 2 h; 2: 4-iodo-benzoic acid methyl ester With zinc(II) chloride in tetrahydrofuran 0.25 h; 3: With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran T=25°C; Negishi coupling reaction; 4 h;
参考文献
Angewandte Chemie - International Edition, , vol. 47, # 36 p. 6802 - 6806
反应条件
1: para-chloro-benzonitrile With diisobutylaluminium hydride; magnesium; lithium chloride in tetrahydrofuran T=25°C; 3 h; 2: 4-iodo-benzoic acid methyl ester With zinc(II) chloride in tetrahydrofuran 0.25 h; 3: With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran T=25°C; Negishi coupling reaction; 4 h;
参考文献
Piller, Fabian M.; Appukkuttan, Prasad; Gavryushin, Andrei; Helm, Matthew; Knochel, Paul
Angewandte Chemie - International Edition, 2008 , vol. 47, # 36 p. 6802 - 6806
反应条件
manganese; cobalt (II) bromide; triphenylphosphine; trifluoroacetic acid in pyridine; N,N-dimethyl-formamide T=50°C;
参考文献
Angewandte Chemie - International Edition, , vol. 47, # 11 p. 2089 - 2092
反应条件
diphenylphosphinyl containing polymer; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran T=20°C; Negishi reaction; 12 h;
参考文献
Yang, Yun-Chin; Luh, Tien-Yau
Journal of Organic Chemistry, 2003 , vol. 68, # 25 p. 9870 - 9873
反应条件
potassium phosphate; trans-[Ni(Naph)Cl(PPh3)2]; tri-cyclo-hexyl-phosphine in tetrahydrofuran T=25°C; Suzuki coupling; 48 h; Inert atmosphere;
参考文献
Leowanawat, Pawaret; Zhang, Na; Safi, Mehtap; Hoffman, David J.; Fryberger, Miriam C.; George, Aiswaria; Percec, Virgil
Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2885 - 2892
反应条件
potassium phosphate; [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane T=100 - 110°C; Suzuki coupling; Inert atmosphere;
参考文献
Chen, Guo-Jun; Han, Fu-She
European Journal of Organic Chemistry, 2012 , # 19 p. 3575 - 3579
反应条件
1: 4-iodo-benzoic acid methyl ester With lithium chloride in N,N-dimethyl-formamide T=80°C; 2: para-iodobenzonitrile With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in N,N-dimethyl-formamide T=80°C; 3 h; Inert atmosphere;
参考文献
Papoian, Vardan; Minehan, Thomas
Journal of Organic Chemistry, 2008 , vol. 73, # 18 p. 7376 - 7379
反应条件
1: 4-hydroxy-benzonitrile With potassium phosphate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane T=100°C; 3 h; Inert atmosphere; 2: (4-methoxycarbonylphenyl)-boronic acid With [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane T=100 - 110°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Chen, Guo-Jun; Huang, Jie; Gao, Lian-Xun; Han, Fu-She
Chemistry - A European Journal, 2011 , vol. 17, # 14 p. 4038 - 4042
反应条件
NiCl2((PPh3)P)2; triphenylphosphine; zinc in tetrahydrofuran T=20°C; Suzuki coupling; 24 h; Inert atmosphere;
参考文献
Huang, Yao-Bing; Yang, Chu-Ting; Yi, Jun; Deng, Xiao-Jian; Fu, Yao; Liu, Lei
Journal of Organic Chemistry, 2011 , vol. 76, # 3 p. 800 - 810
