2-甲基-[1,1-联苯]-4-羧酸甲酯合成路线 （共 20 条）
反应条件
catalyst 1 (aliphatic, phosphine based pincer complex of palladium) in 1,4-dioxane; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; 0.25 h;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 48 p. 12939 - 12941
反应条件
bis(1,5-cyclooctadiene)nickel (0); potassium phosphate; tri-cyclo-hexyl-phosphine in tetrahydrofuran
T=25°C; 12 h; Inert atmosphere;
参考文献
Leowanawat, Pawaret; Zhang, Na; Resmerita, Ana-Maria; Rosen, Brad M.; Percec, Virgil
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 9946 - 9955
反应条件
palladium diacetate; cesium fluoride; 2-dicyclohexylphosphino-1,1'-biphenyl in 1,4-dioxane
T=25°C; Inert atmosphere;
参考文献
Wilson, Daniela A.; Wilson, Christopher J.; Rosen, Brad M.; Percec, Virgil
Organic Letters, 2008 , vol. 10, # 21 p. 4879 - 4882
反应条件
sulfuric acid
6 h; Heating;
参考文献
Ananthakrishnanadar, Ponnambalanad.; Kannan, Nagarathnam
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984 , # 1 p. 35 - 38
反应条件
1: ortho-cresol With potassium phosphate; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane
T=100°C; 3 h; Inert atmosphere;
2: (4-methoxycarbonylphenyl)-boronic acid With [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane
T=100 - 110°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Chen, Guo-Jun; Huang, Jie; Gao, Lian-Xun; Han, Fu-She
Chemistry - A European Journal, 2011 , vol. 17, # 14 p. 4038 - 4042
反应条件
1: 2-MeC6H4MgX, X = halide With zinc(II) chloride in tetrahydrofuran
T=25°C; 0.25 h; Inert atmosphere;
2: 4-Bromo-benzoic acid methyl ester With [(C10H13-1,3-(CH2P(Cy)2)2)Pd(Cl)] in tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; Inert atmosphereResealed tube;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 35 p. 8996 - 9003
反应条件
palladium diacetate; caesium carbonate in tetrahydrofuran
Suzuki coupling;
参考文献
Crombie, Aimee L.; Antrilli, Thomas M.; Campbell, Brandon A.; Crandall, David L.; Failli, Amedeo A.; He, Yanan; Kern, Jeffrey C.; Moore, William J.; Nogle, Lisa M.; Trybulski, Eugene J.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 12 p. 3742 - 3745
反应条件
palladium; triphenylphosphine in tetrahydrofuran
T=70°C; Negishi Coupling; 48 h; Inert atmosphereGreen chemistry; Catalytic behavior;
参考文献
Wu, Wei-Yi; Lin, Tze-Chiao; Takahashi, Tamotsu; Tsai, Fu-Yu; Mou, Chung-Yuan
ChemCatChem, 2013 , vol. 5, # 4 p. 1011 - 1019
参考文献
Otsuka Pharmaceuticals Co., Ltd.
Patent: US6335327 B1, 2002 ;
Location in patent: Page column 96 ;
参考文献
Otsuka Pharmaceuticals Co., Ltd.
Patent: US6335327 B1, 2002 ;
Location in patent: Page column 96 ;
