4’-溴[1,1’-联苯]-4-甲酸甲酯合成路线 (共 9 条)
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethanol; water; toluene T=80°C; 4 h; Heating / reflux;
参考文献
THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC
Patent: WO2006/55725 A2, 2006 ;
Location in patent: Page/Page column 179 ;
WO 2006/055725 A2
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; water Suzuki Coupling; 5 h; Heating / reflux;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2004/242572 A1, 2004 ;
Location in patent: Page/Page column 77 ;
反应条件
4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride
参考文献
Wright, Aaron T.; Song, Joongyu D.; Cravatt, Benjamin F.
Journal of the American Chemical Society, 2009 , vol. 131, # 30 p. 10692 - 10700
反应条件
manganese(IV) oxide; sodium cyanide T=20°C; 15 h;
参考文献
Monguchi, Yasunari; Vagner, Josef; Handl, Heather L.; Jana, Umasish; Begay, Lucinda J.; Hruby, Victor J.; Gillies, Robert J.; Mash, Eugene A.
Tetrahedron Letters, 2005 , vol. 46, # 44 p. 7589 - 7592
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 75 percent / tetrahydrofuran; hexane / 4 h / -78 - 20 °C 2.1: 87 percent / NaCN; MnO2 / 15 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 44 p. 7589 - 7592
参考文献
Fletcher, David I.; Ganellin, C. Robin; Piergentili, Alessandro; Dunn, Philip M.; Jenkinson, Donald H.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 16 p. 5457 - 5479
反应条件
in N,N-dimethyl-formamide T=130°C; 16 h;
参考文献
Fletcher, David I.; Ganellin, C. Robin; Piergentili, Alessandro; Dunn, Philip M.; Jenkinson, Donald H.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 16 p. 5457 - 5479
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 1 h;
参考文献
THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC
Patent: WO2004/99171 A2, 2004 ;
Location in patent: Page 117 ;
WO 2004/099171 A2
反应条件
1: With sodium hydroxide; water in tetrahydrofuran; water 3 h; Heating / reflux; 2: With hydrogenchloride in water
参考文献
Boehringer Ingelheim International GmbH
Patent: US2004/242572 A1, 2004 ;
Location in patent: Page/Page column 77 ;