3-[(叔丁基二甲基甲硅烷基)氧基]-1-丙醇 合成路线 （共 37 条）
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane T=-78°C; 0.666667 h;
参考文献
Pearson; Postich
反应条件
1: 5.36 g / n-BuLi / tetrahydrofuran; hexane / 3 h / -78 °C 2: 97 percent / K2CO3 / methanol / 20 °C View Scheme
参考文献
Nomura, Izumi; Mukai, Chisato
反应条件
in tetrahydrofuran T=0°C;
参考文献
Pearson, William H.; Kropf, Jeffrey E.; Choy, Allison L.; Ill, Young Lee; Kampf, Jeff W.
反应条件
1: 3-(t-butyl-dimethyl-silanyloxy)-propionaldehyde With borane-THF; Nα-(4-methylbenzenesulfonyl)-D-phenylalanine in dichloromethane T=-94°C; 0.25 h; 2: [(1-methoxy-2-methyl-1-propenyl)oxy]trimethylsilane in dichloromethane T=-94 - -78°C; 1.75 h; 3: With Amberlite IRA-743 in dichloromethane; water T=-78 - 20°C; 6 h;
参考文献
Storer, R. Ian; Takemoto, Toshiyasu; Jackson, Philip S.; Ley, Steven V.
反应条件
in benzene 5 h; Heating;
参考文献
Cardani, Silvia; De Toma, Carlo; Gennari, Cesare; Scolastico, Carlo
反应条件
1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; tert-butyl alcohol / 1 h 2: N-(1-chloro-2-methylprop-1-enyl)-N,N-dimethylamine / dichloromethane / 1 h / Inert atmosphere View Scheme
参考文献
Qi, Jun; Blanden, Adam R.; Bane, Susan; Kingston, David G.I.
反应条件
N-chloro-succinimide; L-proline in dichloromethane T=0°C; 18 h; Inert atmosphere;
参考文献
Halperin, Shira D.; Kang, Baldip; Britton, Robert
反应条件
1: 71 percent / Kiyooka's chiral boron reagent
2: 77 percent / Et3N
3: LDA
View Scheme
参考文献
Mulzer, Johann; Mantoulidis, Andreas; Oehler, Elisabeth
→
反应条件
193146-63-3 (3S,6R,7S,8S,12Z,15S,16E)-3,7,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)-5-氧代-十七-12,16-二烯酸
反应条件
1: N-Tos-D-valine, BH3*THF / CH2Cl2 / 4 h / -78 °C
2: 99 percent / 2,6-lutidine / CH2Cl2 / 2 h / 0 °C
3: 2,6-lutidine / CH2Cl2 / 3 h / 0 °C
4: 87 percent / CSA / methanol; CH2Cl2 / 4 h / 0 °C
5: Dess-Martin periodinane / CH2Cl2 / 2 h / 0 °C
6: NaClO2, Na2HPO4, 2,3-dimethylbut-2-ene / 2-methyl-propan-2-ol; H2O / 0.67 h
View Scheme
参考文献
Mulzer, Johann; Mantoulidis, Andreas; Oehler, Elisabeth
→
反应条件
193146-49-5 (3S,6R,7S,8S,12Z,15S,16E)-1,3,15-三-{[叔-丁基(二甲基)硅烷基]氧基}-7-羟基-4,4,6,8,12,16-六甲基-17-(2-甲基-1,3-噻唑-4-基)十七烷基-12,16-二烯-5-酮
反应条件
1: 71 percent / Kiyooka's chiral boron reagent
2: 77 percent / Et3N
3: LDA
View Scheme
参考文献
Mulzer, Johann; Mantoulidis, Andreas; Oehler, Elisabeth
