反应条件
1: 51 percent / triphenylphosphine; di-tert-butyl azodicarboxylate / tetrahydrofuran / 2 h / 25 °C
2: 75 percent / [1,1'-bis(diphenylphosphino)ferrocene]PdCl2(II)*CH2Cl2 / 3 h / 100 °C / 10343.2 Torr
3: 95 percent / aq. NaOH / methanol / 3 h / 25 °C
4: 92 percent / O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium(1+)*BF4(1-); Et3N / dimethylformamide / 1 h / 25 °C / pH 6
5: 52 percent / POCl3 / 6 h / 100 °C
View Scheme
参考文献
Liu, Gang; Lynch, John K.; Freeman, Jennifer; Liu, Bo; Xin, Zhili; Zhao, Hongyu; Serby, Michael D.; Kym, Philip R.; Suhar, Tom S.; Smith, Harriet T.; Cao, Ning; Yang, Ruojing; Janis, Rich S.; Krauser, Joel A.; Cepa, Steven P.; Beno, David W. A.; Sham, Hing L.; Collins, Christine A.; Surowy, Teresa K.; Camp, Heidi S.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 13 p. 3086 - 3100
