2-羟基砒啶-4-羧酸甲酯合成路线 （共 13 条）
反应条件
1: methanol With acetyl chloride T=0 - 20°C; 2: 2-hydroxypyridine-4-carboxylic acid With hydrogenchloride in methyl acetate T=20°C; 16 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; AHMAD, Saleem; WASHBURN, William, N.; HERNANDEZ, Andres, S.; ROBL, Jeffrey, A.; NGU, Khehyong; WANG, Zhenghua
Patent: WO2010/104830 A1, 2010 ;
Location in patent: Page/Page column 70-71 ;
WO 2010/104830 A1
反应条件
methanol T=73°C; 18 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/76387 A1, 2009 ;
Location in patent: Page/Page column 30 ;
WO 2009/076387 A1
反应条件
1: ammonia / H2O / 22 h / 240 °C 2: H2SO4 / 18 h / 75 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 12 p. 4022 - 4036
反应条件
1: HBr; acetic acid / H2O / 22 h / 80 °C 2: 96 mg / H2SO4 / 6 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 12 p. 4022 - 4036
反应条件
sulfuric acid T=75°C; 18 h; Title compound not separated from byproducts;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 12 p. 4022 - 4036
反应条件
1: LiAlH4 2: thionyl chloride View Scheme
参考文献
Taylor, Scott D.; Mirzaei, Farzad; Sharifi, Ali; Bearne, Stephen L.
Journal of Organic Chemistry, 2006 , vol. 71, # 25 p. 9420 - 9430
参考文献
Crawforth, James Michael; Goodacre, Simon Charles; Harrison, Timothy; Hallett, David James; Owens, Andrew Pate; Rowley, Michael; Teall, Martin Richard
Patent: US2002/188000 A1, 2002 ;
反应条件
1: sodium borohydride 2: imidazole / dimethylformamide View Scheme
参考文献
Katagiri; Sato; Kaneko
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 1 p. 288 - 290
参考文献
Crawforth, James Michael; Goodacre, Simon Charles; Harrison, Timothy; Hallett, David James; Owens, Andrew Pate; Rowley, Michael; Teall, Martin Richard
Patent: US2002/188000 A1, 2002 ;
