6-氯-3,4-二氢-2(1H)-喹噁啉酮合成路线 （共 10 条）
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran; toluene
参考文献
The Upjohn Company
Patent: US5541324 A1, 1996 ;
反应条件
ammonium hydroxide; silver nitrate
参考文献
Crowther et al.
Journal of the Chemical Society, 1949 , p. 1260,1268
反应条件
1: AgNO3; aqueous NH3 2: POCl3 View Scheme
参考文献
Crowther et al.
Journal of the Chemical Society, 1949 , p. 1260,1268
反应条件
sodium tetrahydroborate in ethanol
2.5 h; Ambient temperature;
参考文献
Jacobsen, E. Jon; TenBrink, Ruth E.; Stelzer, Lindsay S.; Belonga, Kenneth L.; Carter, Donald B.; Im, Haesook K.; Im, Wha Bin; Sethy, Vimala H.; Tang, Andy H.; VonVoigtlander, Philip F.; Petke, James D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 158 - 175
反应条件
sodium dithionite; potassium carbonate in ethanol; water
T=20°C;
参考文献
Xu, Bailing; Sun, Yan; Guo, Ying; Cao, Yingli; Yu, Tao
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 7 p. 2767 - 2774
反应条件
sodium hydroxide; sodium tetrahydroborate
1.5 h; Ambient temperature;
参考文献
Sakata, Gozyo; Makino, Kenzi; Morimoto, Katsushi
Heterocycles, 1985 , vol. 23, # 1 p. 143 - 151
反应条件
1: 37 percent / methanol; H2O / 24 h / Ambient temperature
2: 82 percent / NaBH4 / ethanol / 2.5 h / Ambient temperature
View Scheme
参考文献
Jacobsen, E. Jon; TenBrink, Ruth E.; Stelzer, Lindsay S.; Belonga, Kenneth L.; Carter, Donald B.; Im, Haesook K.; Im, Wha Bin; Sethy, Vimala H.; Tang, Andy H.; VonVoigtlander, Philip F.; Petke, James D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 158 - 175
反应条件
1: 68 percent Chromat. / Ba(OH)2 / 9 h / 60 - 65 °C
2: 1.2 percent Chromat. / NaBH4, 5percent NaOH / 1.5 h / Ambient temperature
View Scheme
参考文献
Sakata, Gozyo; Makino, Kenzi; Morimoto, Katsushi
Heterocycles, 1985 , vol. 23, # 1 p. 143 - 151
反应条件
1: benzene
2: Raney nickel; ethanol / Hydrogenation
View Scheme
参考文献
Crowther et al.
Journal of the Chemical Society, 1949 , p. 1260,1268
反应条件
sodium hydroxide; sodium tetrahydroborate
1.5 h; Ambient temperatureother reducing agents; Product distribution;
参考文献
Sakata, Gozyo; Makino, Kenzi; Morimoto, Katsushi
Heterocycles, 1985 , vol. 23, # 1 p. 143 - 151
