3-(羟甲基)环丁烷羧酸甲酯合成路线 （共 3 条）
反应条件
1: With borane-THF in tetrahydrofuran
T=-10 - 20°C; 4 h;
2: With dihydrogen peroxide; sodium hydroxide in tetrahydrofuran
2 h;
参考文献
ACHAOGEN, INC.; KASAR, Ramesh; LINSELL, Martin Sheringham; AGGEN, James Bradley; LU, Qing (Jane); WANG, Dan; CHURCH, Tim; MOSER, Heinz E.; PATTEN, Phillip A.
Patent: WO2012/154204 A1, 2012 ;
Location in patent: Page/Page column 67; 68; 69 ;
反应条件
1.1: potassium carbonate / acetone / 2 h / Reflux
2.1: borane-THF / tetrahydrofuran / 4 h / -10 - 20 °C
2.2: 2 h
View Scheme
参考文献
ACHAOGEN, INC.; KASAR, Ramesh; LINSELL, Martin Sheringham; AGGEN, James Bradley; LU, Qing (Jane); WANG, Dan; CHURCH, Tim; MOSER, Heinz E.; PATTEN, Phillip A.
Patent: WO2012/154204 A1, 2012 ;
反应条件
1.1: potassium hydroxide; water / ethanol / 4 h / 105 °C
2.1: potassium carbonate / acetone / 2 h / Reflux
3.1: borane-THF / tetrahydrofuran / 4 h / -10 - 20 °C
3.2: 2 h
View Scheme
参考文献
ACHAOGEN, INC.; KASAR, Ramesh; LINSELL, Martin Sheringham; AGGEN, James Bradley; LU, Qing (Jane); WANG, Dan; CHURCH, Tim; MOSER, Heinz E.; PATTEN, Phillip A.
Patent: WO2012/154204 A1, 2012 ;
