4-碘-2-甲氧基苯甲酸合成路线 （共 13 条）
参考文献
Hodgson; Jenkinson
Journal of the Chemical Society, 1927 , p. 1742,3042
反应条件
thionyl chloride T=0 - 20°C; 18 h; Inert atmosphere;
参考文献
ABBOTT LABORATORIES; CUSACK, Kevin, P.; BREINLINGER, Eric, C.; FIX-STENZEL, Shannon, R.; STOFFEL, Robert, H.; WOLLER, Kevin, R.
Patent: WO2011/71570 A1, 2011 ;
Location in patent: Page/Page column 202 ;
反应条件
sodium hydroxide in tetrahydrofuran
参考文献
Wyeth
Patent: US2003/55047 A1, 2003 ;
US 20030055047 A1
反应条件
1: (i) AlCl3, (ii) aq. NaOH
2: K2CO3
3: Cl2, aq. KOH
View Scheme
参考文献
Kobayashi,S.; Kuraishi,C.
Chemical and Pharmaceutical Bulletin, 1962 , vol. 10, # 12 p. 1137 - 1141
反应条件
potassium hydroxide; chlorine
参考文献
Kobayashi,S.; Kuraishi,C.
Chemical and Pharmaceutical Bulletin, 1962 , vol. 10, # 12 p. 1137 - 1141
反应条件
1: Ca(OH)2, Na2CO3, aq. NaOH
2: Ag2O, aq. NaOH
3: aq. NaOH
View Scheme
参考文献
Kobayashi,S. et al.
Chemical and Pharmaceutical Bulletin, 1963 , vol. 11, # 1 p. 123 - 126
反应条件
1: Ag2O, aq. NaOH
2: aq. NaOH
View Scheme
参考文献
Kobayashi,S. et al.
Chemical and Pharmaceutical Bulletin, 1963 , vol. 11, # 1 p. 123 - 126
反应条件
1: K2CO3
2: Cl2, aq. KOH
View Scheme
参考文献
Kobayashi,S.; Kuraishi,C.
Chemical and Pharmaceutical Bulletin, 1962 , vol. 10, # 12 p. 1137 - 1141
反应条件
1: AlCl3
2: K2CO3
3: Cl2, aq. KOH
View Scheme
参考文献
Kobayashi,S.; Kuraishi,C.
Chemical and Pharmaceutical Bulletin, 1962 , vol. 10, # 12 p. 1137 - 1141
反应条件
alkaline permanganate
参考文献
Hodgson; Jenkinson
Journal of the Chemical Society, 1927 , p. 1741
