2-硝基-3-羟基苯甲酸甲酯合成路线 （共 13 条）
反应条件
1: methanol With thionyl chloride T=0°C; 0.5 h; 2: 3-Hydroxy-2-nitro-benzoic acid 4 h; Heating / reflux;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2007/125405 A2, 2007 ;
Location in patent: Page/Page column 24; 72-73 ;
WO 2007/125405 A2
反应条件
1: methanol With thionyl chloride T=0°C; 0.5 h; 2: 3-Hydroxy-2-nitro-benzoic acid 6 h; Reflux;
参考文献
Gavai, Ashvinikumar V.; DeLucca, George V.; O'Malley, Daniel; Gill, Patrice; Quesnelle, Claude A.; Fink, Brian E.; Zhao, Yufen; Lee, Francis Y.
Patent: US2014/87992 A1, 2014 ;
Location in patent: Paragraph 0314-0315 ;
反应条件
in methanol; diethyl ether T=0°C; 2 h;
参考文献
Tipparaju, Suresh K.; Joyasawal, Sipak; Pieroni, Marco; Kaiser, Marcel; Brun, Reto; Kozikowski, Alan P.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 23 p. 7344 - 7347
反应条件
potassium hydrogencarbonate in N,N-dimethyl-formamide T=40°C; 2 h; Inert atmosphere;
参考文献
Pasceri, Raffaele; Siegel, David; Ross, David; Moody, Christopher J.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3310 - 3317
反应条件
1.1: potassium hydroxide / water / 12 h / |Reflux 2.1: thionyl chloride / 0.5 h / 0 °C 2.2: 6 h / |Reflux View Scheme
参考文献
Nishioka, Hiromi; Ohmori, Yukiko; Iba, Yumiko; Tsuda, Eri; Harayama, Takashi
Heterocycles, 2004 , vol. 64, p. 193 - 198
反应条件
1: palladium 10 on activated carbon; hydrogen / methanol / 2 h / 20 °C / |Inert atmosphere 2: potassium hexacyanoferrate(III) / methanol; aq. phosphate buffer / 16 h / 20 °C / pH 7 / |Inert atmosphere View Scheme
参考文献
Pasceri, Raffaele; Siegel, David; Ross, David; Moody, Christopher J.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3310 - 3317
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C; 2 h; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 8 p. 3310 - 3317
参考文献
Heterocycles, , vol. 64, p. 193 - 198
反应条件
1: methanol. NaOH
2: aqueous NaOH
3: SOCl2
4: aqueous NaOH
5: platinum; ethanol / Hydrogenation
View Scheme
参考文献
Senoh et al.
Nippon Kagaku Zasshi, 1953 , vol. 74, p. 251
Chem.Abstr., 1954 , p. 3959
