反应条件
1: 1.) K2CO3 / 1.) DMF, 23 deg C, 2 h, 2.) DMF, 23 deg C, 14 h
2: 88 percent / LiAlH4 / diethyl ether / 4 h / 23 °C
3: 96 percent / pyridinium chlorochromate / CH2Cl2 / 3.5 h / 0 °C
4: 1.) NaH / 1.) THF, -5 deg C, 30 min, 2.) THF, RT
View Scheme
参考文献
Thakkar, Kshitij; Geahlen, Robert L.; Cushman, Mark
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2950 - 2955
