(6CI,9CI)-4-乙基-2-苯基嘧啶合成路线 （共 9 条）
反应条件
ammonium hydroxide; hydrogen; palladium on activated charcoal in methanol
参考文献
Sakamoto, Takao; Sakasai, Takeji; Yoshizawa, Hiroshi; Tanji, Ken-Ichi; Nishimura, Sumiko; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4554 - 4560
反应条件
1: 88 percent / 1.) sodium methoxide / 1.) methanol, rt., 12 h; 2.) 120 deg C, 20 mmHg, 2 h
2: 85 percent / phosphoryl chloride / 3 h / Heating
3: 96 percent / hydrogen/conc. ammonia / 5percent palladium charcoal / methanol
View Scheme
参考文献
Sakamoto, Takao; Sakasai, Takeji; Yoshizawa, Hiroshi; Tanji, Ken-Ichi; Nishimura, Sumiko; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4554 - 4560
反应条件
1: 85 percent / phosphoryl chloride / 3 h / Heating
2: 96 percent / hydrogen/conc. ammonia / 5percent palladium charcoal / methanol
View Scheme
参考文献
Sakamoto, Takao; Sakasai, Takeji; Yoshizawa, Hiroshi; Tanji, Ken-Ichi; Nishimura, Sumiko; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4554 - 4560
反应条件
1: 88 percent / 1.) sodium methoxide / 1.) methanol, rt., 12 h; 2.) 120 deg C, 20 mmHg, 2 h
2: 85 percent / phosphoryl chloride / 3 h / Heating
3: 96 percent / hydrogen/conc. ammonia / 5percent palladium charcoal / methanol
View Scheme
参考文献
Sakamoto, Takao; Sakasai, Takeji; Yoshizawa, Hiroshi; Tanji, Ken-Ichi; Nishimura, Sumiko; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4554 - 4560
反应条件
0.0833333 h; Heating;
参考文献
Schenone, Pietro; Sansebastiano, Laura; Mosti, Luisa
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 295 - 305
反应条件
1: 94 percent / KOH / methanol / 5 h / Heating
2: 90 percent / 0.08 h / Heating
View Scheme
参考文献
Schenone, Pietro; Sansebastiano, Laura; Mosti, Luisa
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 295 - 305
反应条件
1: 71 percent / NaOEt / ethanol / 1 h / Heating
2: 94 percent / KOH / methanol / 5 h / Heating
3: 90 percent / 0.08 h / Heating
View Scheme
参考文献
Schenone, Pietro; Sansebastiano, Laura; Mosti, Luisa
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 295 - 305
反应条件
hydrogenchloride; n-propyl nitrite in ethanol
2 h; Ambient temperature;
参考文献
Sakamoto, Takao; Sakasai, Takeji; Yoshizawa, Hiroshi; Tanji, Ken-Ichi; Nishimura, Sumiko; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4554 - 4560
反应条件
1: 92 percent / propyl nitrite, HCl / ethanol / 2 h / Ambient temperature
2: 64 percent / pyruvic acid, conc. HCl / aq. ethanol / 6 h / Heating
View Scheme
参考文献
Sakamoto, Takao; Sakasai, Takeji; Yoshizawa, Hiroshi; Tanji, Ken-Ichi; Nishimura, Sumiko; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4554 - 4560
