2-甲基-5-硝基三氟甲苯合成路线 （共 13 条）
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in 1,2-dichloro-ethane T=80°C; 12 h;
参考文献
WO2013/100632 A1, ;
Page/Page column 36 ;
反应条件
1: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / 1,2-dichloro-ethane / 90 °C 2: potassium carbonate / dichloromethane / 3 h / 20 °C 3: palladium 10 on activated carbon; hydrogen / ethanol View Scheme
参考文献
Journal of the American Chemical Society, , vol. 135, # 5 p. 1669 - 1672
反应条件
1: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / 1,2-dichloro-ethane / 12 h / 80 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C
3: palladium on activated charcoal; hydrogen / methanol / 12 h / 20 °C
View Scheme
参考文献
HANMI PHARM CO., LTD.; BAE, In Hwan; SON, Jung Beom; HAN, Sang Mi; KWAK, Eun Joo; KIM, Ho Seok; SONG, Ji Young; BYUN, Eun Young; JUN, Seung Ah; AHN, Young Gil; SUH, Kwee Hyun
Patent: WO2013/100632 A1, 2013 ;
