1-溴-4-甲氧基-2-甲基-5-硝基苯合成路线 （共 7 条）
反应条件
2: Diazotization View Scheme
参考文献
Kermack; Wight
Journal of the Chemical Society, 1935 , p. 1425
反应条件
nitric acid; acetic acid; trifluoroacetic acid in acetic acid
T=-5°C; 2 h;
参考文献
AbbVie Inc.; Abbott GmbH and Co. KG; Geneste, Hervé; Ochse, Michael; Drescher, Karla; Dinges, Jürgen; Jakob, Clarissa
Patent: US2013/116229 A1, 2013 ;
Location in patent: Paragraph 1011 ;
反应条件
nitric acid; acetic anhydride
T=0°C; 1 h; regioselective reaction;
参考文献
Radchenko, Oleg S.; Sigida, Elena N.; Balaneva, Nadezhda N.; Dmitrenok, Pavel S.; Novikov, Vyacheslav L.
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 1 p. 209 - 214
反应条件
bromine in tetrachloromethane
Heating;
参考文献
Julia,M.; Chastrette,F.
Bulletin de la Societe Chimique de France, 1962 , p. 2255 - 2261
反应条件
1: dichloromethane / 20 °C
2: acetic acid; trifluoroacetic acid; nitric acid / acetic acid / 2 h / -5 °C
View Scheme
参考文献
AbbVie Inc.; Abbott GmbH and Co. KG; Geneste, Hervé; Ochse, Michael; Drescher, Karla; Dinges, Jürgen; Jakob, Clarissa
Patent: US2013/116229 A1, 2013 ;
反应条件
potassium carbonate; benzene
参考文献
Kermack; Wight
Journal of the Chemical Society, 1935 , p. 1425
参考文献
Kermack; Wight
Journal of the Chemical Society, 1935 , p. 1425
