乙酸-[2-(4-辛酰基苯基)]乙酯合成路线 （共 4 条）
反应条件
AlCl3, aluminium chloride in dichloromethane T=0 - 20°C;
参考文献
MAPI PHARMA LTD.; MAROM, Ehud; MIZHIRITSKII, Michael; RUBNOV, Shai
Patent: WO2012/56458 A2, 2012 ;
Location in patent: Page/Page column 23 ;
反应条件
1.1: lithium borohydride / tetrahydrofuran / 0.62 h / 0 °C / Inert atmosphere 1.2: pH < 6 2.1: triethylamine / water; methanol / 2 h / 40 °C View Scheme
参考文献
MAPI PHARMA LTD.; MAROM, Ehud; MIZHIRITSKII, Michael; RUBNOV, Shai
Patent: WO2012/56458 A2, 2012 ;
反应条件
1.1: lithium borohydride / tetrahydrofuran / 0.62 h / 0 °C / Inert atmosphere 1.2: pH < 6 2.1: triethylamine / water; methanol / 2 h / 40 °C 3.1: toluene-4-sulfonic acid; hydrogen / palladium on activated charcoal / methanol / 3.83 h / 50 °C / 37503.8 Torr 3.2: 50 - 65 °C View Scheme
参考文献
SYNTHON BV; GIELING, Reinerus Gerardus
Patent: WO2012/41707 A1, 2012 ;
反应条件
1.1: lithium borohydride / tetrahydrofuran / 0.62 h / 0 °C / Inert atmosphere 1.2: pH < 6 2.1: triethylamine / water; methanol / 2 h / 40 °C 3.1: toluene-4-sulfonic acid / toluene / 0.5 h / 50 °C / Reflux 4.1: hydrogen / 5 palladium on charcoal / toluene / 2 h / 30 °C / 26252.6 Torr View Scheme
参考文献
SYNTHON BV; GIELING, Reinerus Gerardus
Patent: WO2012/41707 A1, 2012 ;
