N-Boc-L-烯丙基甘氨酸甲酯合成路线 （共 53 条）
反应条件
1.1: LiHMDS / tetrahydrofuran / 0.5 h / -78 °C
1.2: 83 percent / tetrahydrofuran / 1 h / -78 °C
2.1: 100 percent / H2 / Pd/C / methanol / 12 h / 20 °C
3.1: 80 percent / DCC / CH2Cl2 / 12 h / -20 °C
4.1: 34 percent / 132 h / -196 °C
View Scheme
参考文献
Spantulescu, M. Daniel; Jain, Rajendra P.; Derksen, Darren J.; Vederas, John C.
Organic Letters, 2003 , vol. 5, # 16 p. 2963 - 2965
反应条件
1: Jones reagent / acetone / 0 - 20 °C
2: 466 mg / diethyl ether / 1 h / 20 °C
3: 100 percent / H2 / Pd/C / methanol / 1 h / 20 °C
4: 74 percent / DCC / CH2Cl2 / 12 h / -20 °C
5: 31 percent / 120 h / -196 °C / Photolysis
View Scheme
参考文献
Spantulescu, M. Daniel; Jain, Rajendra P.; Derksen, Darren J.; Vederas, John C.
Organic Letters, 2003 , vol. 5, # 16 p. 2963 - 2965
反应条件
1: 466 mg / diethyl ether / 1 h / 20 °C
2: 100 percent / H2 / Pd/C / methanol / 1 h / 20 °C
3: 74 percent / DCC / CH2Cl2 / 12 h / -20 °C
4: 31 percent / 120 h / -196 °C / Photolysis
View Scheme
参考文献
Spantulescu, M. Daniel; Jain, Rajendra P.; Derksen, Darren J.; Vederas, John C.
Organic Letters, 2003 , vol. 5, # 16 p. 2963 - 2965
反应条件
1: 100 percent / H2 / Pd/C / methanol / 12 h / 20 °C
2: 80 percent / DCC / CH2Cl2 / 12 h / -20 °C
3: 34 percent / 132 h / -196 °C
View Scheme
参考文献
Spantulescu, M. Daniel; Jain, Rajendra P.; Derksen, Darren J.; Vederas, John C.
Organic Letters, 2003 , vol. 5, # 16 p. 2963 - 2965
反应条件
1: 100 percent / H2 / Pd/C / methanol / 1 h / 20 °C
2: 74 percent / DCC / CH2Cl2 / 12 h / -20 °C
3: 31 percent / 120 h / -196 °C / Photolysis
View Scheme
参考文献
Spantulescu, M. Daniel; Jain, Rajendra P.; Derksen, Darren J.; Vederas, John C.
Organic Letters, 2003 , vol. 5, # 16 p. 2963 - 2965
反应条件
1: 83 percent / Cs2CO3 / acetone / 1 h / 30 °C
2: 85 percent / aq. AcOH; TBAF / tetrahydrofuran / 0 - 20 °C
3: Jones reagent / acetone / 0 - 20 °C
4: 466 mg / diethyl ether / 1 h / 20 °C
5: 100 percent / H2 / Pd/C / methanol / 1 h / 20 °C
6: 74 percent / DCC / CH2Cl2 / 12 h / -20 °C
7: 31 percent / 120 h / -196 °C / Photolysis
View Scheme
参考文献
Spantulescu, M. Daniel; Jain, Rajendra P.; Derksen, Darren J.; Vederas, John C.
Organic Letters, 2003 , vol. 5, # 16 p. 2963 - 2965
反应条件
1: 85 percent / aq. AcOH; TBAF / tetrahydrofuran / 0 - 20 °C
2: Jones reagent / acetone / 0 - 20 °C
3: 466 mg / diethyl ether / 1 h / 20 °C
4: 100 percent / H2 / Pd/C / methanol / 1 h / 20 °C
5: 74 percent / DCC / CH2Cl2 / 12 h / -20 °C
6: 31 percent / 120 h / -196 °C / Photolysis
View Scheme
参考文献
Spantulescu, M. Daniel; Jain, Rajendra P.; Derksen, Darren J.; Vederas, John C.
Organic Letters, 2003 , vol. 5, # 16 p. 2963 - 2965
反应条件
1: 93 percent / NaOH / H2O; dioxane / 48 h / 20 °C / pH 9
2: 98 percent / methanol; toluene; hexane / 0.5 h
View Scheme
参考文献
Collier, Philip N; Campbell, Andrew D; Patel, Ian; Taylor, Richard J.K
Tetrahedron, 2002 , vol. 58, # 30 p. 6117 - 6125
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; lithium bromide
T=0°C; Substitution; 1 h;
参考文献
Guillena; Najera
Journal of Organic Chemistry, 2000 , vol. 65, # 22 p. 7310 - 7322
反应条件
1: Et3N; DMAP / CH2Cl2 / 2 h / 20 °C
2: KMnO4; KOH / 2-methyl-propan-2-ol; H2O
View Scheme
参考文献
Morita; Nagasawa; Yahiro; Matsunaga; Kunieda
Organic letters, 2001 , vol. 3, # 6 p. 897 - 899
